Clinical Authority

SiRo Supplements

Discover the molecular science, purity, and clinical dosages behind our formulas.

01 // Identification

What is Collagen?

Collagen is the most abundant structural protein in the human body. It forms the bio-mechanical foundation of skin, tendons, ligaments, and cartilage. During endogenous decline, external supplementation of hydrolyzed peptides provides fibroblasts with the necessary amino acids for neosynthesis.

02 // Kinetics

The Physiological Process

Intake & Digestion

The hydrolyzed collagen peptides enter the gastrointestinal tract. Because they are already enzymatically hydrolyzed, they largely survive stomach acidity intact. In the small intestine, they are absorbed into the bloodstream.

1. Iwai K, et al. (2005). Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates.

Intestinal Absorption

Thanks to their low molecular weight, the peptides pass the intestinal barrier quickly. Within 30 to 90 minutes, they are present in the bloodstream. We recommend taking SiRo FIT before exercising.

2. Virgilio N, et al. (2024). Absorption of bioactive peptides following collagen hydrolysate intake. Frontiers in Nutrition.

Systemic Distribution

Once in the bloodstream, the bioactive peptides distribute across connective tissues, with a clear presence in skin, tendons, and ligaments. There, they locally stimulate fibroblasts.

3. Kawaguchi T, et al. (2012). Distribution of prolylhydroxyproline and its metabolites after oral administration in rats.

Cell Stimulation

In the extracellular matrix, peptides trigger intracellular signaling that stimulates the endogenous production of new collagen and hyaluronic acid.

4. Ohara H, et al. (2010). Collagen-derived dipeptide stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts.

03 // Parameters

Molecular Quality

Select an elemental pillar for macro-analysis of the formula.

Targeted Source

Bovine collagen exhibits the highest molecular homology with human cartilage and is indicated for tendon repair. Marine collagen shows superior results in clinical trials for dermal tissue.

ExtractionBovine / Marine

Bio-HomologyVery High

Type I Dominance

Although dozens of isoforms exist, Type I collagen makes up over 90 percent of the structure in human skin, tendons, ligaments, and bones. Essential for maximum biomechanical integrity.

IsoformType I

PrevalenceOver 90%

FunctionTensile Strength

Clinical Absorption

We hydrolyze the amino acid chains to approximately 2000 Daltons. This is the clinically validated and optimal size for rapid intestinal absorption and immediate tissue distribution.

Weight2000 Dalton (Da)

StateHydrolyzed

Rate15 - 60 minutes

04 // Quantification

The Clinical Dose

An industry phenomenon is 'pixiedusting': adding active molecules in subclinical amounts (2g-5g) merely for the label claim.

Scientific literature consistently shows that adult cell receptors (fibroblasts) only exhibit optimal tissue stimulation at saturation levels starting from 10 grams. At SiRo Supplements, we adhere to a strict dose of 10 grams per serving for maximum tissue regeneration.

3.5g

Market Average

10g

SiRo Dose

05 // Clinical Validation

Research & Tissue Synthesis

An in-depth analysis of the pharmacokinetic protocol optimizing tissue regeneration.

// Reference Study (2017)

Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis

G. Shaw, A. Lee-Bartlett, ..., K. Baar — The American Journal of Clinical Nutrition

Study Design

A randomized, double-blind, placebo-controlled crossover study. 8 healthy subjects received either a placebo or 15g collagen peptides enriched with vitamin C. After 60 minutes of rest, 6 minutes of eccentric loading followed to mechanically trigger collagen synthesis in the tendons.

Conclusion

The intake of the collagen peptides supplemented with vitamin C, taken exactly one hour before eccentric loading, significantly increases natural collagen production.

Results (Figure 3)

The synthesis of type I procollagen was measured in vivo via PINP (a direct biomarker for collagen production). The synthesis showed a spectacular increase compared to placebo and low-dose groups.

PINP (ng/mL*hr)

150

100

Placebo

Gelatin (g)

06 // In Vitro Observation

Evidence of Cell Activity

Visual representation of fibroblast activity in tendon tissue after administration of placebo versus hydrolyzed collagen peptides (+ Vitamin C).

CONTROL Hydrolyzed Collagen

07 // Application

The Protocol

Tendon and connective tissue have an extremely slow metabolism compared to muscles. An incidental dose has no effect; structural recovery requires strict adherence combined with the right timing.

10g / Day The Golden Rule

For actual, structural tissue synthesis, a daily intake is required for at least 6 consecutive weeks. Even on rest days, this 10g dose is essential.

The Daily Timing

T-60Min

The Intake

Take 10g SiRo Collagen. Mix in water or a sports drink, exactly one hour before your training.

T-0Min

The Stimulus

Start your loading. The eccentric movement acts as a pump to push amino acids into the tendon.

T+24Hour

Neosynthesis

Recovery. Cell activity in the tissue is in an elevated state that lasts up to 72 hours.

08 // Literature

Independent Research

Our formulas are exclusively based on peer-reviewed scientific publications.

Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis

Shaw, G., Lee-Bartlett, A. et al. (2017) | Am J Clin Nutr.

Specific Collagen Peptides Improve Joint Stability and Reduce Pain

Zdzieblik, D., Oesser, S. et al. (2017) | Appl Physiol Nutr Metab.

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology

Proksch, E., Segger, D. et al. (2014) | Skin Pharmacol Physiol.

01 // Identification

What is Creatine?

Creatine is an endogenous amino acid derivative, essential in the ATP energy system for explosive muscle contractions. Exogenous supplementation of Creatine Monohydrate increases the intramuscular concentration of phosphocreatine. This facilitates accelerated ATP resynthesis, resulting in delayed muscle fatigue and increased mechanical power output.

02 // Kinetics

The Physiological Process

Intestinal Absorption

Creatine monohydrate has a bioavailability of almost 100%. After intake, it is efficiently absorbed by the intestinal mucosa almost entirely intact, entering the systemic bloodstream for further distribution.

Jäger, R., et al. (2011). Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids, 40(5), 1369-1383.

Systemic Transport

From the bloodstream, free creatine is transported to tissues with high energy demands, primarily skeletal muscles, via active cell transport facilitated by a specific creatine transporter (CreaT1 / SLC6A8).

Snow, R. J., & Murphy, R. M. (2001). Creatine and the creatine transporter: a review. Molecular and Cellular Biochemistry, 224(1-2), 169-181.

Storage

Once creatine enters the sarcolemma (muscle cell), about 60 to 65 percent is phosphorylated by creatine kinase, converting it into phosphocreatine (PCr) to act as the ultimate intracellular energy buffer.

Harris, R. C., et al. (1992). Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clinical Science, 83(3), 367-374.

ATP Resynthesis

During explosive, short-duration muscle contractions, stored phosphocreatine (PCr) rapidly donates its phosphate group to depleted ADP molecules. This almost instantly restores ATP, significantly delaying muscle fatigue.

Kreider, R. B., et al. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation.

03 // Parameters

Molecular Quality

Select an elemental pillar for macro-analysis of the formula.

Creapure® Guarantee

Exclusively Creapure (Germany). Independently tested purity and guaranteed doping-free. Produced in Germany under the strictest guidelines for the highest possible product quality.

OriginGermany (Alzchem)

Purity Level> 99.9%

Monohydrate Superiority

Creatine monohydrate is the undisputed gold standard in sports science. Other forms (like HCL or Ethyl Ester) show no superior absorption over monohydrate in independent research.

MoleculeCreatine Monohydrate

Bioavailability> 99%

SolubilityOptimal

SiRo Matrix

Our formula is 100% pure and contains no unnecessary fillers. Optimal absorption is guaranteed when taken with a carbohydrate source or immediately after training via insulin-mediated transport.

AdditionsNone (100% Pure)

Doping-freeNZVT Certified

DietVegan & Halal

04 // Quantification

The Clinical Dose

To fully benefit from creatine, the phosphocreatine reserves in your muscle cells must become and remain completely saturated.

Although 3 grams a day provides a baseline, recent studies show that 5 grams is more effective for superior performance. At SiRo, we follow these latest insights. To guarantee constant and maximum tissue saturation regardless of body weight or training intensity, we recommend the more powerful dose of 5 grams per day.

Market
Average

SiRo
Dose

05 // Clinical Validation

Research & Muscle Saturation

An in-depth analysis of the pharmacokinetics behind effective creatine storage in the muscle cell.

// Reference Study (1996)

Muscle creatine loading in men

E. Hultman, K. Söderlund, ..., P.L. Greenhaff — Journal of Applied Physiology

Study Design

A foundational study on intramuscular creatine storage. Researchers compared the impact of a classic "loading phase" (20g/day for 6 days followed by 2g/day) with a constant, lower dosage (3g - 5g/day) over 28 days.

Conclusion

A stable, daily intake of just 3 to 5 grams results in exactly the same maximum muscle saturation after 28 days as an intensive loading phase. This consistent protocol also minimizes gastrointestinal complaints and unwanted acute fluid retention.

Results (Saturation)

The total muscle creatine concentration (measured via muscle biopsy in mmol/kg dry muscle mass) shows that the tissue reaches its physiological maximum after 28 days without the need for megadoses.

Total Muscle Creatine (mmol/kg)

160

140

120

100

Base

Day 14

Day 28

Days of Supplementation (5g/day)

06 // In Vivo Observation

Evidence of ATP Regeneration

Visual representation of accelerated ATP resynthesis (energy recovery) in the muscle fiber after an explosive contraction: untrained tissue versus tissue with optimal creatine saturation.

CONTROL Saturated Muscle Cell

07 // Application

The Protocol

Creatine supplementation is purely about cell saturation. An incidental dose for a match has no direct effect; intramuscular buildup requires structural intake.

5g / Day The Consistent Dose

For actual maximum muscle saturation, a daily intake of 5 grams is required, regardless of rest or training days. Once saturated, this 5g remains the perfect dose to maintain phosphocreatine levels at their absolute maximum.

The Kinetic Timeline

T-0Min

The Intake

Take 5g SiRo Creatine daily. Ideally directly after your training combined with carbohydrates or proteins for improved insulin-mediated absorption.

T+30Min

Absorption

Creatine passes the stomach wall and is transported via the bloodstream to the sarcolemma of active skeletal muscles.

T+28Days

Maximum Saturation

The muscle cells are fully saturated with phosphocreatine. You now experience maximum benefits in explosive power and endurance.

08 // Literature

Independent Research

Our formulas are exclusively based on peer-reviewed scientific publications.

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation

Kreider, R.B., Kalman, D.S. et al. (2017) | J Int Soc Sports Nutr.

Muscle creatine loading in men

Hultman, E., Söderlund, K. et al. (1996) | J Appl Physiol.

Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance

Rawson, E.S., Volek, J.S. (2003) | J Strength Cond Res.

08 // Onze producten

Geselecteerde Formule

Collagen Fit Poeder

Bron: Bovine (Solugel®)

39,95€

(128)

Klinische Data & Resultaten

Spierpijn (Na Training)-28%

Snelheid Spierherstel+13%

Gewrichtsfunctionaliteit+22%

Gewrichtsklachten-32%

Ingrediënten

Collageen peptiden10g

Vitamine C120mg

Vitamine D37.50µg

Calcium225mg

Mangaan1mg

Geselecteerde Formule

Collagen Fit Shot (Peach)

Bron: Bovine (Solugel®)

79,95€

(84)

Klinische Data & Resultaten

Spierpijn (Na Training)-28%

Snelheid Spierherstel+13%

Gewrichtsfunctionaliteit+22%

Gewrichtsklachten-32%

Ingrediënten

Collageen peptiden10g

Vitamine C120mg

Calcium80mg

Mangaan1mg

Geselecteerde Formule

Collagen Skin Poeder

Bron: Marine (Naticol®)

59,50€

(56)

Dermale Klinische Data

Huiddichtheid & Stevigheid+8%

Elasticiteit van de Huid+7%

Hydratatieniveau+14%

RimpelreductieZichtbaar Effect

Ingrediënten

Collageen peptiden10g

Vitamine C80mg

IJzer0.25mg

Selenium13.75µg

Zink5mg

Geselecteerde Formule

Collagen Skin Shot

Bron: Marine (Naticol®)

99,50€

(42)

Dermale Klinische Data

Huiddichtheid & Stevigheid+8%

Elasticiteit van de Huid+7%

Hydratatieniveau+14%

RimpelreductieZichtbaar Effect

Ingrediënten

Collageen peptiden10g

Vitamine C80mg

Zink5mg

09 // Kennisbank

Veelgestelde Vragen

Wat is SiRo Collagen FIT precies?

SiRo Collagen FIT is een voedingssupplement op basis van Peptan, een gepatenteerd bovine (runder-)collageenpeptide type I. Eén dagdosis levert een klinische dosis collageenpeptiden, aangevuld met vitamine C, calcium, mangaan en vitamine D3. Het is ontwikkeld voor wie pezen, banden, gewrichten en bindweefsel structureel wil ondersteunen.

Waarom bovine collageen in plaats van marine (vis-)collageen?

Bovine type I-collageen is het meest onderzochte type voor pezen, banden en bindweefsel, en ligt qua profiel het dichtst bij menselijk kraakbeen. Voor huidgerichte doelen gebruikt SiRo bewust marine collageen (in de SKIN-lijn), elk type ingezet waar het onderzoek het sterkst is.

Hoeveel collageen zit er in één dagdosis en is dat genoeg?

Eén standaard dagdosis levert exact 10 gram Peptan-collageenpeptiden, wat het wetenschappelijke minimum is voor actieve weefselstimulatie bij volwassenen. Onze formule is tevens aangevuld met vitamine C, wat biochemisch essentieel is voor de daadwerkelijke neosynthese in het lichaam.

Na hoe lang merk ik resultaat?

Zoals bij de meeste collageensupplementen wordt minimaal 6 tot 12 weken continu gebruik aanbevolen, omdat de opbouw van pezen en bindweefsel een uiterst langzaam biologisch proces is in vergelijking met spierweefsel. Consistentie is veel belangrijker dan incidenteel hoge dosissen.

Waarom SiRo Collagen FIT kiezen boven een goedkoper alternatief?

Vier concrete verschillen: (1) Gepatenteerde, traceerbare Peptan peptiden; (2) 10g klinisch gedoseerd per dag tegenover subklinische doses bij budgetmerken; (3) NZVT-batchcontrole voor dopingvrijheid; (4) Vervaardigd onder strenge kwaliteitsnormen (FAVV) in België.

SiRo Supplements

What is Collagen?

The Physiological Process

Intake & Digestion

Intestinal Absorption

Systemic Distribution

Cell Stimulation

Molecular Quality

Targeted Source

Type I Dominance

Clinical Absorption

The Clinical Dose

Research & Tissue Synthesis

Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis

Study Design

Conclusion

Results (Figure 3)

Evidence of Cell Activity

The Protocol

The Daily Timing

The Intake

The Stimulus

Neosynthesis

Independent Research

What is Creatine?

The Physiological Process

Intestinal Absorption

Systemic Transport

Storage

ATP Resynthesis

Molecular Quality

Creapure® Guarantee

Monohydrate Superiority

SiRo Matrix

The Clinical Dose

Research & Muscle Saturation

Muscle creatine loading in men

Study Design

Conclusion

Results (Saturation)

Evidence of ATP Regeneration

The Protocol

The Kinetic Timeline

The Intake

Absorption

Maximum Saturation

Independent Research

Klinische Data & Resultaten

Ingrediënten

Klinische Data & Resultaten

Ingrediënten

Dermale Klinische Data

Ingrediënten

Dermale Klinische Data

Ingrediënten

Klinische Data & Prestaties

Ingrediënten

Veelgestelde Vragen